LINDEN LAKE FOCUS AREAS

Novel Therapeutic Biologics. A biologic drug (biologics) is a product that is produced from living organisms or contains components of living organisms. Biologic products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system. In particular, we are targeting biospecific antibodies, antibody-drug conjugates, engineered T-cell receptors and other immunomodulators.

Gene/Nucleic Acid-Based Therapies. Gene therapy is a therapeutic technique that uses genes to treat or prevent disease. Approaches to gene therapy include: replacing a mutated gene that causes disease with a healthy copy of the gene, inactivating, or “knocking out/down,” a mutated gene that is functioning improperly; and introducing a new gene into the body to help fight a disease. In particular we will focus on technologies related to mRNA, RNAi, miRNA, viral expression vectors, aptamers and CRISPR/CAS9 gene editing.

Cell/Regenerative Therapies. Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage or congenital defects. It includes the injection of stem cells or progenitor cells (also known as cell-based therapies), the induction of regeneration by biologically active molecules, and transplantation of in vitro grown organs and tissues. We are particularly interested in Chimeric Antigen Receptor T Cells (CAR-T), induced pluripotent stem (iPS) cells and engineered tissues.

Therapeutic Modality Optimization Platforms and Personalized Medicine. Personalized or precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. Personalized medicine platforms will leverage advanced genomics/proteomics in combination with bioinformatics and artificial intelligence (AI)